TLR7 Polymorphism (rs179008 and rs179009) in HIV-Infected Individual Naïve to ART
Table 4
Frequency distribution of TLR7 polymorphisms (rs179008, Gln11Leu (A/T) and rs179009, IVS2-151 (A/G) in HIV disease stages and healthy controls.
TLR7 rs179008 A/T genotypes
Healthy controls (%)
Early HIV disease stage
Intermediate HIV disease stage
Advanced HIV disease stage
(%)
OR ()
(%)
OR ()
(%)
OR ()
AA
128 (81.0%)
38 (95.0%)
1 (reference)
33 (94.3%)
1 (reference)
60 (93.8%)
1 (reference)
AT
26 (16.5%)
2 (5.0%)
0.26, (0.09)
2 (5.7%)
0.30 (0.15)
2 (3.1%)
0.16 (0.01)
TT
4 (2.5%)
0 (0.0%)
NS
0 (0.0%)
NS
2 (3.1%)
1.07 (0.71)
TLR7 rs179009 A/G genotypes
Healthy controls (%)
Early HIV disease stage
Intermediate HIV disease stage
Advanced HIV disease stage
(%)
OR ()
(%)
OR ()
(%)
OR ()
AA
100 (63.3%)
38 (95.0%)
1 (reference)
33 (94.3%)
1 (reference)
60 (93.8%)
1 (reference)
AG
46 (29.1%)
2 (5.0%)
0.11 (0.001)
5 (5.7%)
0.03 (0.04)
3 (4.7%)
0.11 (≤0.001)
GG
12 (7.6%)
0 (0.0%)
NS
0 (0.0%)
NS
1 (1.6%)
0.14 (0.03)
= umber of subjects; % = frequency of genotypes/alleles. The presence of AA for AT, TT for rs179008, AA for AG, GG for rs179009, and A allele for T and A allele for G was taken as a reference group for statistical analysis.
