TLR7 Polymorphism (rs179008 and rs179009) in HIV-Infected Individual Naïve to ART
Table 5
Frequency distribution of TLR7 polymorphisms (rs179008, Gln11Leu (A/T) and rs179009, IVS2-151 (A/G)) in tobacco and alcohol using HIV-infected individuals and nonusers.
TLR7 rs179008 A/T genotypes
Tobacco users (%)
Tobacco nonusers (%)
value
OR 95% CI
CC
19 (82.6%)
101 (82.8%)
1
Reference
CT
3 (13.0%)
17 (13.9%)
0.81
0.94 (0.20-3.89)
TT
1 (4.3%)
4 (3.3%)
0.70
1.33 (cornfield limits invalid)
TLR7 rs179009 A/G genotypes
Tobacco users (%)
Tobacco nonusers (%)
value
OR 95% CI
AA
15 (65.2%)
90 (73.8%)
1
Reference
AG
6 (26.1%)
21 (17.2%)
0.47
1.71 (0.52-5.49)
GG
2 (8.7%)
11 (9.0%)
0.75
1.09 (0.0-6.09)
TLR7 rs179008 A/T
Alcohol users (%)
Alcohol nonusers (%)
value
OR 95% CI
AA
20 (87.0%)
104 (81.9%)
1
Reference
AT
3 (13.0%)
18 (14.2%)
0.91
0.87 (0.18-3.55)
TT
0 (0.0%)
5 (3.9%)
—
NS
TLR7 rs179009 A/G
Alcohol users (%)
Alcohol nonusers (%)
value
OR (95% CI)
AA
18 (78.3%)
92 (72.4%)
1
Reference
AG
4 (17.4%)
23 (18.1%)
0.92
0.89 (0.23-3.17)
GG
1 (4.3%)
12 (9.4%)
0.68
0.43 (0.02-3.53)
= number of subjects; % = frequency of genotypes/alleles. The presence of AA for AT, TT for rs179008, AA for AG, GG for rs179009, and A allele for T and A allele for G was taken as a reference group for statistical analysis.
