High-Pressure Pneumoperitoneum Aggravates Surgery-Induced Neuroinflammation and Cognitive Dysfunction in Aged Mice

Figure 1

The study design. Experiment 1: animals were subjected to the novel object recognition (NOR) test on postoperative day 3 (d3), the training of fear conditioning (FC) was applied on d4, and the FC test was performed on d5. Experiment 2: animals were sacrificed 24 hours after surgery, and the hippocampus was collected for ELISA and immunostaining.