Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis

Table 3

Risk factors for 28-day mortality in septic patients by univariate and multivariate Cox proportional hazards regression analysis.

Variables	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
Age (≥69 vs. <69)	1.74 (0.54-5.39)	0.365
Hypertension (yes vs. no)	1.01 (0.97–1.06)	0.71
Chronic renal disease (yes vs. no)	1.19 (0.71–1.91)	0.49
APACHE II score (high vs. low)	1.37 (0.90–2.01)	0.17
SOFA score (high vs. low)	1.35 (1.01–1.91)	0.038	1.39 (0.86–2.19)	0.12
SAPS III score (high vs. low)	1.65 (1.18–2.27)	0.017	1.62 (0.66–3.63)	0.27
Septic shock (yes vs. no)	2.31 (1.26–4.47)	0.011	2.43 (1.42–3.91)	0.021
Mechanical ventilation (yes vs. no)	1.63 (0.65–3.77)	0.28
Renal replacement therapy (yes vs. no)	2.67 (0.80–8.33)	0.19
Norepinephrine therapy (yes vs. no)	1.01 (0.95–1.07)	0.48
Lactic acid (high vs. low)	1.09 (1.01–1.26)	0.022	1.72 (0.96–3.05)	0.09
CRP (high vs. low)	1.31 (1.05–1.62)	0.013	1.37 (0.75–2.42)	0.24
PCT (high vs. low)	1.40 (0.66–2.96)	0.37
AFR (high vs. low)	0.84 (0.75–0.94)	0.009	0.67 (0.42–0.93)	0.018

APACHE: Acute Physiology and Chronic Health Evaluation; SOFA: Sepsis-related Organ Failure Assessment; SAPS: Simplified Acute Physiology Score; CRP: C-reactive protein; PCT: procalcitonin; AFR: albumin-to-fibrinogen ratio; HR: hazard ratio; CI: confidence interval. .