Research Article
Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro
Figure 2
NaB shows protective effect on Aβ-induced N2a cell viability decrease. (a) Effect of Aβ25-35 on N2a cell viability. Cells were incubated with 0, 40, 60, or 80 μM Aβ25-35 for 24 hours (, , Student’s -test, , and ). (b) Effect of 2 mM NaB pretreatment on cell viability challenged by 40 μM Aβ25-35 for 24 hours. Cells were starved for 4 h and then pretreated with 2 mM NaB for 2 h before Aβ25-35 was added. Cell viability was analyzed by the CCK-8 assay (, , Student’s -test, , and ). When the concentration of Aβ is 40 μM, it had caused obvious damage to the N2a cells. After pretreatment with 2 mM NaB, cell viability was restored.
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