Increased Levels of Soluble CD206 Associated with Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis

Table 2

Predictive factors for RP-ILD in DM patients using univariate and age- and gender-adjusted multivariate logistic regression analyses.

Predictor	Univariate analysis			Age- and gender-adjusted multivariate analysis
	Odds ratio	95% CI	value	Odds ratio	95% CI	value
Age (yrs)	1.005	0.974-1.036	0.767
Gender (female)	1.279	0.501-3.264	0.607
Anti-MDA-5-positive	3.584	1.530-8.393	0.003	3.910	1.629-9.382	0.002
Anti-ARS-positive	2.025	0.813-5.042	0.130	1.988	0.795-4.974	0.142
sCD206 (ng/ml)	1.004	1.003-1.006	<0.0001	1.005	1.003-1.007	<0.0001
CRP (mg/dl)^a	1.054	0.981-1.131	0.149	1.052	0.979-1.131	0.166
ESR (mm/H)^b	1.019	1.003-1.035	0.017	1.020	1.004-1.036	0.015
Ferritin (ng/ml)^c	1.002	1.001-1.003	0.002	1.002	1.001-1.004	0.002
%FVC (%)^d	0.929	0.893-0.966	<0.0001	0.928	0.892-0.964	<0.0001
CK (IU/l)	1.000	1.000-1.000	0.989	1.000	1.000-1.000	0.964
Muscle weakness	0.542	0.237-1.240	0.147	0.541	0.235-1.245	0.149
Heliotrope sign	0.748	0.331-1.688	0.485	0.752	0.333-1.699	0.493
Gottron papules	1.732	0.729-4.113	0.213	1.734	0.729-4.123	0.213
Mechanic’s hands	2.633	1.151-6.023	0.022	2.593	1.125-5.976	0.025
Skin ulcer	1.432	0.544-3.769	0.467	1.517	0.567-4.059	0.406
Arthritis/arthralgia	1.150	0.488-2.707	0.750	1.143	0.485-2.695	0.760
Dysphagia	0.641	0.240-1.709	0.374	0.613	0.224-1.675	0.340
Elevated sCD206 (≥792.75 ng/ml)	11.222	4.466-28.200	<0.0001	12.679	4.844-33.182	<0.0001
Elevated ferritin (≥417.7 ng/ml)^c	7.837	2.690-22.830	<0.0001	11.416	3.383-38.525	<0.0001

DM: dermatomyositis; RP-ILD: rapidly progressive interstitial lung disease; sCD206: soluble CD206; ARS: aminoacyl-tRNA synthetases; MDA-5: melanoma differentiation-associated gene-5; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; CK: creatine kinase; %FVC: percent predicted forced vital capacity. ^a,b,c,dData were available for 140, 142, 85, and 94 patients, respectively.