Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions

<div>Immunofluorescence staining of glial cells in the corpus callosum of wild-type and db/db mice with sham or BCAS operation for four weeks. (a) Representative images of GFAP-positive astrocytes. (b) Histogram of GFAP-positive astrocytes density in different groups. (c) Representative images of Iba-1-positive microglia. (d) Histogram of Iba-1-positive microglia density in different groups. (e) Representative images of Olig-2-positive oligodendrocytes. 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Mediators of Inflammation

fig4

Figure 4

Figure 4: Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions 