Dynamic Monitoring of sTREM-1 and Other Biomarkers in Acute Cholangitis

Table 3

Sensitivity and specificity of WBC, CRP, PCT, sTREM-1, and T for distinguishing Group B from Group C.

Index	AUC^ROC	Cut-off	Sensitivity	Specificity	95% CI	PPV (%)	NPV (%)	LR(+)	LR(-)
WBC	0.859	8.95	0.750	0.974	0.759-0.958	93.1	89.2	28.85	0.26
CRP	1.000	9.45	1.000	1.000	1.000-1.000	100.0	100.0	—	0.00
PCT	0.902	0.345	0.778	0.921	0.835-0.969	82.4	89.7	9.85	0.24
T	0.574	37.25	0.417	0.868	0.446-0.702	60.0	75.9	3.16	0.67
sTREM-1	0.868	229.65	0.694	0.868	0.799-0.937	71.4	85.7	5.26	0.35

Group B: AC patients without sepsis; Group C: individuals without AC or other infections. AUC^ROC: area under ROC curves; 95% CI: 95% confidence interval; PPV: positive predictive value; NPV: negative predictive value; LR(+): positive likelihood ratio; LR(-): negative likelihood ratio. CRP showed the highest AUC ( test, ) to diagnose AC without sepsis.