Dynamic Monitoring of sTREM-1 and Other Biomarkers in Acute Cholangitis

Table 4

Sensitivity and specificity of WBC, CRP, PCT, sTREM-1, and T for distinguishing Group A from Group C.

Index	AUC^ROC	Cut-off	Sensitivity	Specificity	95% CI	PPV (%)	NPV (%)	LR(+)	LR(-)
WBC	0.939	9.25	0.828	1.000	0.881-0.997	100.0	93.8	—	0.17
CRP	1.000	12.95	1.000	1.000	1.000-1.000	100.0	100.0	—	0.00
PCT	0.975	0.675	0.966	1.000	0.926-1.000	100.0	98.7	—	0.03
T	0.838	37.25	0.724	0.868	0.735-0.941	67.7	89.2	5.48	0.32
sTREM-1	0.971	255.2	0.931	0.908	0.944-0.998	79.4	97.2	10.12	0.08

Group A: AC patients with sepsis; Group C: individuals without AC or other infections. AUC^ROC: area under ROC curves; 95% CI: 95% confidence interval; PPV: positive predictive value; NPV: negative predictive value; LR(+): positive likelihood ratio; LR(-): negative likelihood ratio. CRP and PCT showed the higher AUC^ROC ( test, ). The AUC^ROC of CRP and PCT had no significant difference ( test, ).