Dynamic Monitoring of sTREM-1 and Other Biomarkers in Acute Cholangitis
Table 5
Sensitivity and specificity of single indexes and different index combinations for distinguishing Group A from Group B.
Index
AUCROC
Cut-off
Sensitivity
Specificity
95% CI
PPV (%)
NPV (%)
LR(+)
LR(-)
WBC
0.567
9.35
0.828
0.417
0.426-0.707
53.3
75.0
1.42
0.41
CRP
0.513
148.5
0.483
0.694
0.365-0.662
56.0
62.5
1.58
0.74
PCT
0.758
3.83
0.759
0.722
0.639-0.876
68.7
78.8
2.73
0.33
T
0.750
37.35
0.655
0.722
0.631-0.869
65.5
72.2
2.36
0.48
sTREM-1
0.737
446
0.586
0.861
0.616-0.857
77.3
72.1
4.22
0.48
WBC & CRP
0.572
0.400
0.793
0.417
0.431-0.712
52.3
71.4
1.36
0.50
WBC & PCT
0.745
0.350
0.793
0.722
0.624-0.866
69.7
81.2
2.85
0.29
WBC & T
0.741
0.441
0.655
0.750
0.622-0.861
67.9
73.0
2.62
0.46
WBC & sTREM-1
0.784
0.610
0.552
0.944
0.669-0.898
88.9
72.3
9.86
0.47
CRP & PCT
0.76
0.351
0.793
0.694
0.642-0.877
67.6
80.6
2.59
0.30
CRP & T
0.735
0.413
0.724
0.750
0.612-0.857
70.0
77.1
2.90
0.37
CRP & sTREM-1
0.778
0.510
0.621
0.833
0.664-0.891
75.0
73.2
3.72
0.45
PCT & T
0.774
0.379
0.759
0.694
0.659-0.889
66.7
78.1
2.48
0.35
PCT & sTREM-1
0.745
0.487
0.586
0.861
0.625-0.865
77.3
72.1
4.22
0.48
T & sTREM-1
0.797
0.437
0.724
0.806
0.686-0.908
75.0
78.4
3.73
0.34
WBC & CRP & PCT
0.744
0.354
0.690
0.722
0.626-0.862
66.7
74.3
2.48
0.43
WBC & CRP & T
0.740
0.417
0.724
0.750
0.618-0.863
70.0
77.1
2.90
0.37
WBC & CRP & sTREM-1
0.791
0.515
0.621
0.833
0.682-0.901
75.0
73.2
3.72
0.45
WBC & PCT & T
0.778
0.330
0.828
0.611
0.667-0.889
63.2
81.5
2.13
0.28
WBC & PCT & sTREM-1
0.781
0.603
0.552
0.944
0.665-0.897
88.9
72.3
9.86
0.47
WBC & T & sTREM-1
0.820
0.461
0.759
0.778
0.718-0.921
73.3
80.0
3.42
0.31
CRP & PCT & T
0.780
0.419
0.690
0.778
0.663-0.896
71.4
75.7
3.11
0.40
CRP & PCT & sTREM-1
0.775
0.383
0.793
0.694
0.660-0.890
67.6
80.6
2.59
0.30
CRP & T & sTREM-1
0.803
0.464
0.690
0.833
0.692-0.913
76.9
76.9
4.13
0.37
PCT & T & sTREM-1
0.793
0.382
0.793
0.694
0.682-0.904
67.6
80.6
2.59
0.30
WBC & CRP & PCT & T
0.786
0.455
0.655
0.861
0.675-0.897
79.2
75.6
4.71
0.40
WBC & CRP & PCT & sTREM-1
0.797
0.469
0.655
0.833
0.688-0.906
76.0
75.0
3.92
0.41
WBC & CRP & T & sTREM-1
0.833
0.653
0.552
0.944
0.736-0.930
88.9
72.3
9.86
0.47
WBC & PCT & T & sTREM-1
0.825
0.467
0.690
0.861
0.724-0.926
80.0
77.5
4.96
0.36
CRP & PCT & T & sTREM-1
0.797
0.468
0.690
0.806
0.685-0.909
74.1
76.3
3.56
0.38
WBC & CRP & PCT & T & sTREM-1
0.824
0.615
0.586
0.944
0.723-0.925
89.5
73.9
10.46
0.44
Group A: AC patients with sepsis; Group B: AC patients without sepsis. AUCROC: area under ROC curves; 95% CI: 95% confidence interval; PPV: positive predictive value; NPV: negative predictive value; LR(+): positive likelihood ratio; LR(-): negative likelihood ratio. PCT showed the highest AUCROC ( test, ) to diagnose sepsis in patients with AC, followed by T and sTREM-1. Different combination of indexes did not enhance the diagnostic power ( test, ).
