MEG3 Alleviated LPS-Induced Intestinal Injury in Sepsis by Modulating miR-129-5p and Surfactant Protein D

<div>Overexpression of MEG3 inhibited the intestinal injury in vivo via downregulating miR-129-5p. (a) MEG3 expression in the intestinal tissues of the sepsis group infected with LV-NC or LV-MEG3. (b) miR-129-5p expression in the intestinal tissues of the sepsis group infected with LV-NC or LV-MEG3. (c) Apoptotic cells were indicated by TUNEL assay (200× magnification). (d) Cleaved caspase-3 protein expression was evaluated using the Western blot analysis. (e) Villus length was quantified in sections of the jejunum. ELISA analysis of IL-6 (f) and TNF-<i>α</i> (g) levels in intestine tissues. Three independent experiments were carried out. 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Mediators of Inflammation

fig2

Figure 2

Figure 2: MEG3 Alleviated LPS-Induced Intestinal Injury in Sepsis by Modulating miR-129-5p and Surfactant Protein D 