Monocyte Chemotactic Protein 1-Induced Protein 1 Is Highly Expressed in Inflammatory Bowel Disease and Negatively Regulates Neutrophil Activities

Figure 1

MCPIP-1 is highly increased in neutrophils of IBD patients. Peripheral neutrophils were isolated from patients with active CD () or active UC () and healthy donors (HC, ). The protein levels of MCPIP were determined by Western blotting (a) and quantified in gray value (b). . Abbreviation: ns, not significant. (c) Representative images of double immunofluorescence staining for MCPIP-1 (green) and myeloperoxidase (MPO, red) expression in inflamed colon from an active CD and an active UC patient, and normal colon mucosa of a HC. The arrows indicate double-positive cells after merging (original magnification ×100 and insert ×200). (d) The histogram represents the percentage of double-positive cells in lamina propria of intestinal mucosa from HC (), UC (), and CD () patients per high-power field (HPF). . Abbreviation: ns, not significant.

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