Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis

Figure 1

Scatterplot of interferon-gamma (IFN-γ) and interleukin-4 (IL-4) at cryptococcal meningitis diagnosis in CSF versus serum. IFN-γ is a Th1 cytokine which is protective in cryptococcosis causing classical activation of macrophages to enhance killing of yeast. IL-4 is Th2 cytokine which is not protective in mouse models of cryptococcosis. Both cytokines have a weak, inverse correlation between levels observed in serum versus CSF. Levels are in pg/mL.