Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis

Table 1

Correlation of paired CSF and serum analytes at baseline, 1-week, and 2-week post cryptococcal meningitis diagnosis.

Biomarker	At CM diagnosis			1-week post diagnosis			2-week post-CM diagnosis
		Rho	value		Rho	value		Rho	value
Innate immune response
IL-6	160	0.021	0.79	105	-0.025	0.80	115	-0.228	0.01
IL-1β	160	-0.042	0.60	105	-0.122	0.22	115	0.052	0.58
IL-8	160	-0.034	0.67	105	0.141	0.15	115	0.035	0.71
G-CSF	160	-0.003	0.97	105	0.1	0.31	115	0.087	0.36
GM-CSF	160	0.033	0.68	105	0.16	0.10	115	0.25	0.007
MCP-1	160	0.133	0.09	105	0.216	0.03	115	-0.117	0.21
MIP-1α	75	0.01	0.93	5	0.4	0.51	93	-0.07	0.51
MIP-1β	160	0.117	0.14	105	0.114	0.25	115	-0.057	0.55
CD14	87	0.078	0.47	n	N/A	N/A	83	0.187	0.09
CD163	87	-0.249	0.02	n	N/A	N/A	83	-0.099	0.38
Adaptive immune response
IFN-γ	160	-0.214	0.007	105	0.089	0.37	115	0.198	0.03
TNF-α	160	0.077	0.33	105	0.038	0.70	115	0.078	0.41
IL-12	160	0.09	0.26	105	-0.153	0.12	115	-0.005	0.96
IL-2	160	-0.025	0.76	105	-0.041	0.68	115	0.22	0.02
IL-7	160	0.038	0.64	105	0.11	0.26	115	-0.004	0.96
IL-10	160	0.021	0.80	105	0.045	0.65	115	-0.025	0.80
IL-5	160	-0.046	0.56	105	0.099	0.32	115	0.004	0.97
IL-4	160	-0.232	0.003	105	0.107	0.28	115	-0.064	0.49
IL-13	160	0.056	0.48	105	-0.004	0.97	115	-0.057	0.54
IL-17	160	-0.008	0.92	105	0.128	0.19	115	0.012	0.90
Hemostasis
VEGF	111	-0.049	0.61	62	0.062	0.63	115	-0.002	0.99

value of less than 0.01. Interleukin: IL; interferon: IFN; tumor-necrosis factor: TNF; granulocyte colony-stimulating factor: G-CSF; granulocyte-macrophage colony-stimulating factor: GM-CSF; monocyte chemoattractant protein-1/CCL2: MCP-1; macrophage inflammatory protein: MIP; and vascular endothelial growth factor: VEGF.