Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis

Table 2

Correlation of CSF and serum cytokines pooled across all three time points at baseline, 1-week, and 2-week post cryptococcal meningitis diagnosis.

Biomarkers	Combined Correlation			Rate of Change Over Time
		Rho	value		Rho	value
Innate immune response
IL-6	403	-0.07	0.16	160	0.151	0.06
IL-1β	403	0.029	0.57	160	0.070	0.38
IL-8	403	0.029	0.56	160	0.132	0.10
G-CSF	403	0.067	0.18	160	0.086	0.28
GM-CSF	403	0.147	0.003	160	-0.030	0.70
MCP-1	403	0.073	0.15	160	0.111	0.16
MIP-1α	214	-0.127	0.06	118	0.061	0.51
MIP-1β	403	0.10	0.05	160	-0.119	0.13
CD14	312	0.095	0.09	128	0.180	0.04
CD163	312	-0.051	0.37	128	-0.143	0.11
Adaptive immune response
IFN-γ	403	0.119	0.02	160	0.120	0.13
TNF-α	403	0.102	0.04	160	0.096	0.23
IL-12	403	-0.021	0.67	160	-0.003	0.97
IL-2	403	0.089	0.08	160	-0.057	0.48
IL-7	403	0.036	0.47	160	-0.032	0.69
IL-10	403	-0.062	0.21	160	0.068	0.40
IL-5	403	0.041	0.41	160	0.059	0.46
IL-4	403	0.082	0.10	160	-0.063	0.43
IL-13	403	-0.093	0.06	160	0.194	0.014
IL-17	403	0.066	0.19	160	-0.082	0.30
Hemostasis
VEGF	307	0.051	0.37	147	-0.059	0.48

value of less than 0.01. Interleukin: IL; interferon: IFN; tumor-necrosis factor: TNF; granulocyte colony-stimulating factor: G-CSF; granulocyte-macrophage colony-stimulating factor: GM-CSF; monocyte chemoattractant protein-1/CCL2: MCP-1; macrophage inflammatory protein: MIP; and vascular endothelial growth factor: VEGF.