Mediators of Inflammation

Research Article

Cangfudaotan Decoction Alleviates Insulin Resistance and Improves Follicular Development in Rats with Polycystic Ovary Syndrome via IGF-1-PI3K/Akt-Bax/Bcl-2 Pathway

Table 1

Characteristics of chemical components in CFD by UHPLC-Q-TOF/MS analysis.


No.	Component name	Retention time	Formula	Precursor mass	Found at mass	Mass error (ppm)	Library score	Isotope ratio difference

1	L(+)-Arginine	1.08	C₆H₁₄N₄O₂	175.119	175.1191	0.7	89.8	1.0
2	Betaine	1.16	C₅H₁₁NO₂	118.086	118.0865	2.0	100.0	0.4
3	Trigonelline	1.20	C₇H₇NO₂	138.055	138.0552	2.1	95.8	0.2
4	Proline	1.23	C₅H₉NO₂	116.071	116.0709	2.3	97.8	0.6
5	Stachydrine	1.26	C₇H₁₃NO₂	144.102	144.1019	-0.3	96.4	1.3
6	Nicotinic acid	1.73	C₆H₅NO₂	124.039	124.0396	2.4	99.5	0.1
7	Adenosine	3.68	C₁₀H₁₃N₅O₄	268.104	268.1044	1.4	100.0	1.8
8	Guanosine	4.12	C₁₀H₁₃N₅O₅	284.099	284.0995	2.0	100.0	2.2
9	Phenprobamate	4.78	C₉H₁₁NO₂	166.086	166.0865	1.3	95.7	0.8
10	Esculin hydrate	5.88	C₁₅H₁₆O₉	341.087	341.0881	4.0	92.4	2.8
11	Chlorogenic acid	6.24	C₁₆H₁₈O₉	355.102	355.1027	0.9	99.5	0.4
12	Fraxetin	7.25	C₁₀H₈O₅	209.044	209.0449	2.3	75.6	0.8
13	Eriodictyol	7.88	C₁₅H₁₂O₆	289.071	289.0713	2.1	84.4	1.7
14	Polygalaxanthone IV	7.88	C₂₇H₃₂O₁₅	597.181	597.1823	1.4	74.6	3.8
15	Liquiritigenin	7.94	C₁₅H₁₂O₄	257.081	257.0814	2.3	95.3	4.3
16	Scopoletin	8.07	C₁₀H₈O₄	193.050	193.0500	2.6	91.4	2.5
17	Isoferulic acid	8.09	C₁₀H₁₀O₄	195.065	195.0657	2.6	97.0	1.1
18	Isorhamnetin	8.17	C₁₆H₁₂O₇	317.066	317.0664	2.6	70.4	2.9
19	Narirutin	8.47	C₂₇H₃₂O₁₄	581.186	581.1872	1.2	97.6	0.9
20	Naringenin	8.48	C₁₅H₁₂O₅	273.076	273.0762	1.6	100.0	0.2
21	Hesperetin	8.82	C₁₆H₁₄O₆	303.086	303.0865	0.6	99.4	0.9
22	Hesperidin	8.82	C₂₈H₃₄O₁₅	611.197	611.1975	0.7	84.1	1.8
23	Apigenin 7-O-beta-D-glucuronide	9.37	C₂₁H₁₈O₁₁	447.092	447.0928	1.4	100.0	2.6
24	6,7-Dimethoxycoumarin	9.40	C₁₁H₁₀O₄	207.065	207.0656	2.2	96.5	1.5
25	Xanthotoxol	10.13	C₁₁H₆O₄	203.034	203.0344	2.4	74.6	1.5
26	Wogonin 7-O-glucuronide	10.45	C₂₂H₂₀O₁₁	461.108	461.1087	1.9	100.0	1.0
27	Glycocholic acid	11.34	C₂₆H₄₃NO₆	466.316	466.3168	1.1	79.8	2.7
28	Sodium glycocholate	11.34	C₂₆H₄₂NNaO₆	488.298	488.2987	0.9	97.0	3.3
29	Baicalein	11.64	C₁₅H₁₀O₅	271.060	271.0604	1.1	89.1	0.8
30	Glycyrrhetinic acid	12.04	C₃₀H₄₆O₄	471.347	471.3474	1.0	83.7	2.8
31	Formononetin	12.06	C₁₆H₁₂O₄	269.081	269.0812	1.4	91.2	1.1
32	Bergapten	12.10	C₁₂H₈O₄	217.050	217.0500	2.1	96.3	3.6
33	Limonin	12.54	C₂₆H₃₀O₈	471.201	471.2020	1.4	97.0	0.4
34	Patchouli alcohol	12.61	C₁₅H₂₄	205.195	205.1955	2.0	85.5	3.9
35	Wogonin	12.90	C₁₆H₁₂O₅	285.076	285.0762	1.7	93.6	2.1
36	Nobiletin	12.93	C₂₁H₂₂O₈	403.139	403.1387	-0.2	94.7	1.6
37	Chrysin	12.99	C₁₅H₁₀O₄	255.065	255.0660	3.2	84.7	2.1
38	Nomilin	13.07	C₂₈H₃₄O₉	515.228	515.2286	2.0	89.6	0.2
39	Tangeretin	13.62	C₂₀H₂₀O₇	373.128	373.1280	-0.5	98.3	1.6
40	Curdione	13.65	C₁₅H₂₄O₂	237.185	237.1853	1.8	92.1	2.0
41	Obacunone	13.67	C₂₆H₃₀O₇	455.206	455.2075	2.3	76.3	0.4
42	Costunolide	15.09	C₁₅H₂₀O₂	233.154	233.1542	2.5	91.1	1.5
43	α-Cyperone	15.41	C₁₅H₂₂O	219.174	219.1748	1.9	87.8	1.3
1	L(+)-Arginine	1.06	C₆H₁₄N₄O₂	173.104	173.1043	-0.6	95.9	0.7
2	Aspartic acid	1.09	C₄H₇NO₄	132.030	132.0302	-0.5	84.0	0.8
3	D-(+)-Glucose	1.18	C₆H₁₂O₆	179.056	179.0559	-0.9	78.3	0.1
4	Quinic acid	1.23	C₇H₁₂O₆	191.056	191.0559	-1.1	91.3	1.1
5	Maltopentaose	1.27	C₃₀H₅₂O₂₆	827.267	827.2664	-1.3	97.4	1.6
6	L-Malic acid	1.30	C₄H₆O₅	133.014	133.0141	-1.0	86.4	0.2
7	Citric acid	1.98	C₆H₈O₇	191.020	191.0196	-0.4	99.4	0.3
8	Uridine	2.52	C₉H₁₂N₂O₆	243.062	243.0621	-0.8	78.5	1.2
9	Guanosine	4.10	C₁₀H₁₃N₅O₅	282.084	282.0841	-0.9	98.2	2.1
10	Phenprobamate	4.77	C₉H₁₁NO₂	164.072	164.0714	-1.7	98.4	1.7
11	Protocatechuic acid	5.23	C₇H₆O₄	153.019	153.0191	-1.7	96.0	0.8
12	Vanillic acid	5.52	C₈H₈O₄	167.035	167.0348	-1.3	81.2	2.3
13	L-Tryptophan	5.82	C₁₁H₁₂N₂O₂	203.083	203.0823	-1.7	93.1	0.6
14	Protocatechuic aldehyde	6.14	C₇H₆O₃	137.024	137.0243	-0.7	97.2	0.3
15	Chlorogenic acid	6.23	C₁₆H₁₈O₉	353.088	353.0876	-0.5	100.0	0.4
16	A3-N-butyl-4,5-Dihydrophthalide	6.53	C₁₂H₁₆O₂	191.108	191.1076	-0.6	77.2	3.3
17	Caffeic acid	6.72	C₉H₈O₄	179.035	179.0349	-0.5	83.5	1.6
18	Rutin	7.61	C₂₇H₃₀O₁₆	609.146	609.1455	-1.0	96.6	1.1
19	p-Coumaric acid	7.66	C₉H₈O₃	163.040	163.0400	-0.7	99.0	0.3
20	Hyperin	7.85	C₂₁H₂₀O₁₂	463.088	463.0878	-0.9	87.3	4.0
21	Neoeriocitrin	7.88	C₂₇H₃₂O₁₅	595.167	595.1663	-0.9	95.1	0.7
22	Liquiritin	7.93	C₂₁H₂₂O₉	417.119	417.1187	-1.0	98.1	1.7
23	Isoferulic acid	8.08	C₁₀H₁₀O₄	193.051	193.0505	-0.8	97.6	0.3
24	Naringin	8.47	C₂₇H₃₂O₁₄	579.172	579.1712	-1.2	96.2	2.0
25	Isochlorogenic acid C	8.62	C₂₅H₂₄O₁₂	515.119	515.1190	-1.0	98.5	0.1
26	Baicalin	9.36	C₂₁H₁₈O₁₁	445.078	445.0772	-1.0	99.4	1.2
27	Cistanoside D	9.73	C₃₁H₄₀O₁₅	651.229	651.2284	-1.7	88.6	4.5
28	Isoliquiritigenin	9.87	C₁₅H₁₂O₄	255.066	255.0660	-1.0	92.7	0.8
29	Eriodictyol	9.96	C₁₅H₁₂O₆	287.056	287.0556	-1.7	98.9	2.9
30	Xanthotoxol	10.12	C₁₁H₆O₄	201.019	201.0190	-1.6	91.2	0.9
31	Wogonin 7-O-glucuronide	10.44	C₂₂H₂₀O₁₁	459.093	459.0928	-1.1	98.1	0.9
32	Naringenin	10.95	C₁₅H₁₂O₅	271.061	271.0610	-0.9	99.4	0.5
33	Hesperetin	11.30	C₁₆H₁₄O₆	301.072	301.0715	-1.0	95.7	0.7
34	Glycocholic acid	11.34	C₂₆H₄₃NO₆	464.302	464.3010	-1.6	78.0	0.3
35	Baicalein	11.64	C₁₅H₁₀O₅	269.046	269.0454	-0.6	94.0	2.4
36	Glycoursodeoxycholic acid	11.88	C₂₆H₄₃NO₅	448.307	448.3067	-0.3	95.2	0.8
37	Glycyrrhizic acid	12.03	C₄₂H₆₂O₁₆	821.397	821.3955	-1.2	92.1	2.3
38	Eupatilin	12.45	C₁₈H₁₆O₇	343.082	343.0819	-1.1	98.1	3.2
39	Chrysin	12.99	C₁₅H₁₀O₄	253.051	253.0503	-1.4	78.2	1.2
40	Chrysosplenetin B	13.05	C₁₉H₁₈O₈	373.093	373.0924	-1.3	94.3	0.9
41	Ursodeoxycholic acid	13.19	C₂₄H₄₀O₄	391.285	391.2848	-1.4	96.4	2.3
42	Asiatic acid	13.77	C₃₀H₄₈O₅	487.343	487.3419	-2.1	73.2	2.9
43	Dioscin	14.97	C₄₅H₇₂O₁₆COOH^-	913.480	913.4789	-1.5	76.9	2.2