Identification of miRNA-mRNA Crosstalk in Respiratory Syncytial Virus- (RSV-) Associated Pediatric Pneumonia through Integrated miRNAome and Transcriptome Analysis

Table 1

Characteristics of patients with mild and severe RSV-associated pediatric pneumonia.

Clinical information	Mild ()	Severe ()	value
Male gender, (%)	14 (60.9%)	13 (56.5%)	0.765
Age (months)			0.813
Underlying comorbidities, (%)	2 (8.7%)	8 (34.8%)	0.074
Clinical presentation, (%)
Fever	23 (100%)	23 (100%)	1.000
Physical examination, (%)
Tachypnea^a	0 (0%)	20 (87.0%)	0.000
Laboratory examination^b
White blood cell (×10^9/L)^c			0.893
C-reactive protein (CRP)^d (mg/L)	9.00 (5.00-19.79)	14.20 (11.00-19.00)	0.030
Radiology, (%)
Patchypacity^e	23 (100%)	23 (100%)	1.000
Management
Oxygen therapy, (%)	0 (0%)	20 (87.0%)	0.000
Ventilator support, (%)	0 (0%)	3 (13.0%)	0.233
Duration of wheezing^f (days)			0.000
Duration of hospital stay (days)	7.00 (5.00-8.00)	11.00 (8.00-16.00)	0.000

Data was presented as number (percentage), median (25th-75th percentile), or deviation, where appropriate, and compared with the chi-squared test, independent-samples -test, and Mann-Whitney test, respectively. For all analyses, 2-tailed values were calculated by IBM SPSS statistics 25.0. Statistical significance was defined as . ^aRespiratory breaths/min. ^bData extracted from the first test for the children on admission. ^cThe normal reference value was . ^dThe normal reference value was (0-3) mg/L. ^eJudged by chest radiograph or CT scan in the whole course of the patients. ^fWheezing duration from onset to relief.