Recombinant Erythropoietin Provides Protection against Renal Fibrosis in Adenine-Induced Chronic Kidney Disease

Figure 5

rEPO induces colocalization of EPOR and βcR in Ad-CKD rats. Immunofluorescence staining micro images for EPOR (first line), βcR (second line), merged images of EPOR/βcR (third line), and DAPI (fourth line) (40x). Scale bar is 20 μm. The control group shows EPOR reactivity, no βcR, and thus no coexpression. The Ad-CKD group displays EPOR some βcR and no coexpression. The Ad-CKD+rEPO group shows increased expression of EPOR and βcR and coexpression of the heteroreceptor as depicted by orange dots (yellow arrows).