Effects of Shikonin on the Functions of Myeloid Dendritic Cells in a Mouse Model of Severe Aplastic Anemia

Figure 3

(a) The CD86+ mDCs in the AA group significantly increased compared with those of the NC and TBI groups (). After the treatments, the CD86 levels in the shikonin and CsA groups decreased significantly compared with that in the AA group (). (b) The CD80+ mDCs in the AA group significantly increased compared with those in the NC group (). The CD80 levels in the CsA group decreased compared with those in the AA group (). (c) The glucose consumption levels in mDCs of the AA group were significantly higher than those in the TBI and NC groups, while those in the shikonin and CsA groups were significantly lower than those in the AA group (). (d) The pyruvate levels in mDCs of the AA group were significantly higher than those in the TBI and NC groups, while those in the shikonin and CsA groups were significantly lower than those in the AA group (). (e) The ATP contents in mDCs in the AA group were significantly higher than those in the TBI and NC groups, while those in the shikonin and CsA groups were significantly lower than those in the AA group (). AA: aplastic anemia (); TBI: total body irradiation (); NC: normal control (); shikonin (); CsA: cyclosporin A (); NS: normal saline () ().

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