Anti-Inflammatory Profile of Jungia sellowii Less. by Downregulation of Proinflammatory Mediators and Inhibition of NF-κB and p38 Pathways

Figure 4

(a) Effects of the isolated compounds curcuhidroquinone O-β-glucose (CUR: 2.5 mg/kg) and piptizol (Pip: 1 mg/kg) from J. sellowii L. roots administered 0.5 h prior to carrageenan (1% Cg, i.pl.) on total and phosphorylated protein (p-p65 of NF-κB) in the lungs; (b) effects of the isolated compounds curcuhidroquinone O-β-glucose (CUR: 2.5 mg/kg) and piptizol (Pip: 1 mg/kg) from J. sellowii L. roots administered 0.5 h prior to carrageenan (1% Cg, i.pl.) on total and phosphorylated protein (p-p38 MAPK) in the lungs. Sal: negative control group, animals treated only with sterile saline (NaCl, 0.9%); Cg: positive control group, animals treated only with 1% Cg; Dex: animals pretreated with dexamethasone (0.5 mg/kg). The results were expressed in relative fold change in comparison to Sal, which represents the basal level of p65 and p38 MAPK phosphorylation. Bars represent the of five animals. ANOVA: Newman-Keuls test.

(a)

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