Fibrinogen as a Prognostic Predictor in Pediatric Patients with Sepsis: A Database Study

Table 3

Univariate and multivariate logistic regression about laboratory parameters in patients with sepsis.

Parameters	Training set ()					Validation set ()
	Univariate logistic analysis		Multivariate logistic analysis				Univariate logistic analysis		Multivariate logistic analysis
	OR (95% CI)		OR (95% CI)				OR (95% CI)		OR (95% CI)
Complications
Respiratory failure	1.439 (1.235, 1.676)	<0.001	1.338 (1.137, 1.574)	<0.001			1.626 (1.299, 2.036)	<0.001	1.426 (1.056, 1.925)	0.020
Shock	1.471 (1.236, 1.751)	<0.001	1.292 (1.066, 1.566)	0.009			1.894 (1.523, 2.354)	<0.001
Gastrointestinal disorder	1.396 (1.007, 1.935)	0.046					2.149 (1.638, 2.820)	<0.001	1.454 (1.014, 2.086)	0.042
Acute kidney injury	1.433 (1.054, 1.947)	0.022					2.403 (1.674, 3.448)	<0.001	1.766 (1.127, 2.767)	0.013
Heart failure	1.475 (1.071, 2.033)	0.017					2.012 (1.355, 2.986)	<0.001	1.626 (1.007, 2.624)	0.047
Disturbance of consciousness	1.627 (1.219, 2.171)	0.001	1.580 (1.165, 2.144)	0.003			3.829 (2.592, 5.657)	<0.001	3.342 (2.164, 5.161)	<0.001
Biochemical parameters
Lac	1.417 (1.302, 1.542)	<0.001	1.346 (1.217, 1.489)	<0.001			1.487 (1.329, 1.664)	<0.001	1.274 (1.126, 1.442)	<0.001
PT	1.110 (1.057, 1.165)	<0.001					1.183 (1.094, 1.280)	<0.001
APTT	1.017 (1.008, 1.025)	<0.001					1.008 (1.001, 1.016)	0.028
Fibrinogen	0.586 (0.488, 0.703)	<0.001	0.767 (0.628, 0.937)	0.009			0.412 (0.315, 0.538)	<0.001	0.619 (0.435, 0.880)	0.008
DBIL	1.014 (1.005, 1.023)	0.002					1.026 (1.010, 1.042)	0.002
γ-GT	1.003 (1.000, 1.005)	0.040					1.009 (1.004, 1.014)	<0.001
BUN	1.059 (1.026, 1.092)	<0.001					1.203 (1.090, 1.327)	<0.001
PLT	0.994 (0.992, 0.996)	<0.001					0.990 (0.987, 0.993)	<0.001

Lac: lactate; PT: prothrombin time; APTT: activated partial thromboplastin time; DBIL: direct bilirubin; γ-GT: γ-glutamyl transpeptidase; BUN: blood urea nitrogen; PLT: platelet.