Inhibition of the PERK/TXNIP/NLRP3 Axis by Baicalin Reduces NLRP3 Inflammasome-Mediated Pyroptosis in Macrophages Infected with Mycobacterium tuberculosis

Figure 3

Baicalin prevents the colocalization of TXNIP and NLRP3 in Mtb-infected macrophages. (a, b) Confocal microscopy of RAW264.7 cells with different treatments immunostained with anti-TXNIP (red), anti-NLRP3 (green), and DAPI (blue). of colocalization of TXNIP and NLRP3, TXNIP and NLRP3 florescence intensity in three independent pictures was shown as scatter plot and error bar (). Kruskal-Wallis rank and inspection was used as the statistical analysis method. According to the statistical results of Kruskal-Wallis rank sum test, . The difference between the three groups was statistically significant.

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