Inhibition of the PERK/TXNIP/NLRP3 Axis by Baicalin Reduces NLRP3 Inflammasome-Mediated Pyroptosis in Macrophages Infected with Mycobacterium tuberculosis

Figure 7

Schematic summary of baicalin inhibiting pyroptosis in Mtb-infected macrophages. Previous study has revealed that baicalin inhibits the NF-κB pathway contributing to the inhibitory effect on NLRP3 inflammasome activation [9]. In the present study, we demonstrated that baicalin also inhibits the activation of the PERK pathway, thus attenuating the production of TXNIP and subsequently alleviating the activation of NLRP3 inflammasome resulting in ameliorating pyroptosis in Mtb-infected macrophages.