Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Table 4

Association of genotype and allele distribution of SNPs in CD14. NF-κΒ. TLR2 and TLR4 and occurrence of combined endpoint (stroke/TIA. myocardial infarction. Cardiovascular death. Death from stroke).

	All patients	No or mild periodontitis	Severe periodontitis	value
CD14: rs2569190
CC (%)	30.6	31.9	24.1	0.074
CT (%)	46.2	44.6	54.6
TT (%)	23.2	23.5	21.3
C (%)	53.7	54.2	51.4	0.429
T (%)	46.3	45.8	48.6
NF-κΒ: rs28362491
II (%)	32.7	33.5	28.9	0.537
ID (%)	51.4	50.9	53.5
DD (%)	15.9	15.6	17.6
I (%)	58.4	58.9	55.6	0.332
D (%)	41.6	41.1	44.4
TLR2: rs5743708
AA (%)	94.5	94.4	95.1	1.000
AG (%)	5.4	5.5	4.9
GG (%)	0.1	0.1	0
A (%)	97.2	97.1	97.6	0.840
G (%)	2.8	2.9	2.4
TLR4: rs4986790
AA (%)	91.2	91.5	89.6	0.590
AG (%)	8.6	8.3	10.4
GG (%)	0.2	0.2	0.0
A (%)	95.5	95.6	94.8	0.650
G (%)	4.5	4.4	5.2

Fisher’s exact test.