Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Table 5

Cox regression analysis evaluating the hazard ratio (HR) of the CT genotype of CD14 SNP rs2569190 for the incidence of the (a) combined endpoint (stroke/TIA, myocardial infarction, cardiovascular death, and death from stroke) and (b) cardiovascular death within a 3-year follow-up period (adjusted for age, gender, smoking, body mass index, hypertension, hyperlipoproteinemia, diabetes, and severe periodontitis).

Confounding variables	Hazard ratio	95% lower	CI upper	P values
(a) Endpoint: stroke/TIA, myocardial infarction, cardiovascular death, and death from stroke
CT genotype rs2569190	1.572	1.012	2.439	0.044
Age	1.063	1.035	1.092	<0.001
Diabetes	2.366	1.501	3.729	<0.001
Male gender	1.302	0.784	2.162	0.309
Current smoking	1.572	0.469	5.262	0.463
Hypertension	1. 413	0.706	2.828	0.329
Hyperlipoproteinemia	1.037	0.657	1.636	0.876
Severe periodontitis	1.121	0.721	1.742	0.613
(b) Endpoint: cardiovascular death
CT genotype rs2569190	1.585	1.020	2.500	0.040
Age	1.063	1.035	1.092	<0.001
Diabetes	2.366	1.501	3.729	<0.001
Male gender	1.280	0.772	2.125	0.339
Current smoking	1.563	0.467	5.233	0.469
Hypertension	1. 411	0.705	2.825	0.331
Hyperlipoproteinemia	1.052	0.6668	1.658	0.826
Severe periodontitis	1.116	0.717	1.736	0.626