Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto’s Thyroiditis Patients

Table 2

Clinical characteristics of the participants of the study (HT: Hashimoto patients; BMI: body mass index; TSH: thyroid-stimulating hormone; TPO-Ab: thyroid peroxidase antibody; TG-Ab: thyroid peroxidase antibody; SSA/Ro-Ab: anti-Sjögren’s syndrome type A antibody; SSB/La-Ab: anti-Sjögren’s syndrome type B antibody; HOMA-IR: homeostatic model assessment index; TG: triglyceride; NO: nitric oxide; UWS: unstimulated whole saliva; ND: not detectable; NS: statistically insignificant).

	Control, (min-max)	HT, (min-max)
Age (years)	34.3 (27.2–42)	34.5 (27.8–41.5)	NS
BMI (kg/m^2)	20.5 (19.35–23.96)	21.7 (19.2–24.61)	NS
TSH (μU/mL)	1.23 (0.48–2.3)	1.56 (0.7–2.99)	NS
Free T4 (ng/mL)	1.36 (1.1–1.39)	1.26 (0.76–1.62)	NS
Free T3 (pg/mL)	2.26 (1.75–3.96)	2.86 (2.63–4.51)	NS
TPO-Ab (IU/mL)	0.5 (0.36–2.51)	625.6 (132.4–768)	<0.0001
TG-Ab (IU/mL)	0.4 (0.23–1.91)	318.3 (145.8–437)	<0.0001
SSA/Ro-Ab	ND	ND
SSB/La-Ab	ND	ND
Glucose (mg/dL)	79.56 (72.35–85.01)	83.01 (73.56–88.05)	NS
Insulin (mU/mL)	4.25 (3–11.2)	3.89 (3–10.9)	NS
HOMA-IR	0.89 (0.53–2.41)	0.8 (0.51–2.39)	NS
Witamin 25-OH D3 (ng/mL)	47 (32–51.1)	42.98 (30–50)	NS
TG (mg/dL)	52 (39–79.56)	49 (36–85.21)	NS
CRP mg/L	0.4 (0.2–0.8)	0.63 (0.23–0.92)	NS
HT duration (years)	0	5.8 (3.8–8.3)	<0.0001
Thyroid gland’s nodules	ND	ND
NO UWS (μmol/mg protein)	0.15 (0.01-0.08)	0.26 (0.02–0.56)	0.0011
NO plasma (μmol/mg protein)	0.09 (0.014- 0.19)	0.08 (0.016–0.24)	0.9082