Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto’s Thyroiditis Patients

Table 3

Effect of Hashimoto’s disease on cytokine levels in saliva and plasma. IL: 1α, 1β, 1RA, 2, 2RA, 3,4, 5,6,7,8,9, 10, 12 (p40), 12 (p70), 13, 15, 16, 17, 18-interleukin: 1α, 1β, 1RA, 2, 2RA, 3,4, 5,6,7,8,9, 10, 12 (p40), 12 (p70), 13, 15, 16, 17, 18; IFN-γ: interferon-γ; IFN-α2: interferon-α2; TNF-α, β: tumor necrosis factor α, β; HGF: hepatocyte growth factor; MIF: macrophage migration inhibitory facto;, ND: no detectable.

	Saliva					Plasma
	Control group		Study group		value	Control group		Study group		value
		Median (min-max)		Median (min-max)			Median (min-max)		Median (min-max)
IL-3		38.88 (7-56)		45 (13-80)	0.0074		27.47 (19.79-35.24)		36.01 (19.1-58.72)	<0.0001
IFN-γ		23.57 (12.23-54.5)		43.54 (19.11-81.46)	<0.0001		169.5 (43.5-236)		233.2 (123-427.9)	0.0001
IL-5		6.05 (0.6-9.4)		8.6 (1.2-15.65)	0.015		94.43 (7.968-320.2)		158.5 (41.24-301.3)	0.003
IL-6		73.59 (19-136)		103 (17-297)	0.0187		3.147 (1.568-4.517)		5.202 (0.7955-9.66)	0.0002
TN-α		6.975 (0.625-21.68)		15.15 (1.28-37.39)	0.0003		12.63 (6.019-27.13)		21.27 (6.815-38.84)	<0.0001
IL-12 (p40)		12 (6.614-21.75)		19.5 (8.004-29.9)	<0.0001		13.81 (8.131-21.28)		17.59 (6.718-33.75)	0.0211
HGF		3.842 (1.599-6.273)		5.373 (3.063-8.694)	0.0012		60.69 (43.81-74.71)		75.83 (66.35-103.7)	<0.0001
IL-1α		766.1 (189.2-1375)		1148 (408.2-2182)	0.0223		271 (15-970)		417.5 (39.38-1619)	0.0741
IL-1β		74.05 (22.53-245.4)		153.3 (28.93-343.5)	0.0223		17.28 (1.302-33.61)		24.38 (8.663-48.13)	0.017
IL-1RA		5071 (917-7936)		6707 (3196-10575)	0.0071		12.01 (0.7689-31.98)		17.87 (4.071-40.51)	0.02
IL-8		1479 (87.75-3855)		882 (21-5426)	0.0429		25.36 (6.595-38.56)		7.724 (-5.24-27.19)	<0.0001
IL-10		26.5 (10.22-47)		19 (2.235-40.22)	0.0049		35.14 (13.04-49.94)		21.76 (4.953-47.42)	0.0004
IL-2		30 (4-46)		29 (9.218-58)	0.6685		129.7 (18.51-189.3)		144.7 (25.42-298.6)	0.1213
IL-2RA		37.13 (3.823-86.66)		39 (2.598-87)	0.9578		27.91 (22.57-34.75)		32.49 (19.24-37.89)	0.0389
IL-4		15 (2-33.5)		18 (9-36)	0.0625		24.39 (15.87-31.69)		26.8 (1.017-47.67)	0.3067
IL-7		18 (9.391-25)		16.5 (4.807-42)	0.455		4.495 (1.972-10.08)		6.964 (0.6749-17.65)	0.1035
IL-9		47 (16.48-82)		55 (12.07-99)	0.1806		48.04 (21.43-91.61)		58.96 (8.061-92.59)	0.2799
IL-12 (p70)		22.79 (3.101-36.6)		24 (9.988-36.5)	0.2907		16.96 (3.493-30.17)		20.41 (2.664-44.17)	0.0102
IL-13		1.027 (0.3138-1.833)		1.137 (0.1965-2.41)	0.2022		9 (3.549-21.14)		12 (5.41-22)	0.0161
IL-15		10.2 (0.473-23)		9.6 (2.85-35.3)	0.7619	ND	ND	ND	ND	ND
IL-16		941.6 (80.27-2125)		1012 (235.8-2163)	0.5253		129 (11.15-587)		141.5 (5.34-780)	>0.9999
IL-17	ND	ND	ND	ND	ND		29.5 (21.41-58)		26.6 (8.334-56.7)	0.0466
IL-18		331.5 (10.73-1999)		280 (4.705-1829)	0.9847		22.17 (3.895-33.62)		21.47 (2.131-57.12)	0.6581
IFN-α2		4.539 (2.918-7.328)		5.054 (1.601-10.47)	0.3859		22.29 (9.482-34.99)		21.31 (2.789-39.93)	0.8777
MIF		661 (258.2-1424)		601 (119.5-2221)	0.4185		208 (44.66-340.8)		184.4 (81.59-359.2)	0.8929
TNF-β		5.986 (0.7912-9.791)		7.033 (1.758-11.87)	0.0925		6.997 (1.33-10.08)		10.01 (-2.785-17.23)	0.0028