Mediators of Inflammation

Research Article

Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto’s Thyroiditis Patients

Table 4

Effect of Hashimoto’s disease on chemokine levels: CCL27/CTACK: chemokine ligand 3/monocyte chemoattractant protein-1; CCL3/MIP-1-α: chemokine ligands 3/macrophage inflammatory protein1-alpha; CCL4/MIP-1 β: chemokine ligands 4/macrophage inflammatory protein1 β; β -NGF: β-nerve growth factor; CCL5/RANTES: chemokine ligand 5/regulated on activation, normal T cell expressed and secreted; SCF: stem cell factor; SCGF-β: stem cell growth factor-β; CCL7/MCP-3: chemokine ligand 7/monocyte-chemotactic protein 3; CCL11/eotaxin: chemokine ligand 11/eatoksin; CCL27/CTACK: chemokine ligand 27/cutaneous T cell-attracting chemokine; CXCL1/GRO-α: chemokine (C-X-C motif) ligand 1/growth-regulated oncogene-alpha; CXCL9/MIG: chemokine (C-X-C motif) ligand 9/monokine induced by gamma interferon; CXCL10/IP-10: chemokine (C-X-C motif) ligand 10/interferon gamma-induced protein 10; LIF: leukemia inhibitory factor; CXCL12/SDF-1 α: chemokine (C-X-C motif) ligand 12/stromal cell-derived factor 1; ND: no detectable.


	Saliva					Plasma
	Control group		Study group		value	Control group		Study group		value
		Median (min-max)		Median (min-max)	value		Median (min-max)		Median (min-max)	value

CCL27/CTACK		18.08 (8.970-33.69)		20.27 (11.53-36.62)	0.0195		72.93 (39.18-111.6)		128.3 (60-375.5)	<0.0001
CXCL1/Gro-α		8235 (1768 -15622)		15456 (3393-30180)	0.0005		18731 (3763-33741)		21785 (4134-29760)	0.2092
CCL2/MCP-1		707.8 (198-1490)		677 (24.52-2896)	0.7583		4.557 (0.2395-9.026)		5.865 (1.748-19.22)	0.0189
CCL3/MIP-1α		28 (5.895-118.5)		28 (7.238-354)	0.7914		120.1 (11.45-268.1)		141.4 (5.762-375.2)	0.5768
CCL4/MIP-1β		54.5 (27.5-138)		63 (2.401-129.5)	0.8362		117 (16.15-276.7)		140.4 (16.26-332.6)	0.6721
β-NGF		66 (8.513-116.3)		61 (8.457-143.3)	0.4973		82.24 (6.667-179.1)		99.81 (33.11-275.2)	0.263
CCL5/RANTES		2.927 (0.394-4.531)		3.201 (1.084-6.698)	0.2218		1470 (519.6-2704)		1740 (465.3-4047)	0.0916
SCF		72 (5.96-150)		76 (6.221-314)	0.7914		33.06 (17.22-50.29)		55.61 (27.62-89.57)	<0.0001
SCGF-β		54.5 (27.5-138)		63 (2.401-129.5)	0.8362		560.9 (43.81-1213)		658.4 (150.4-1260)	0.2467
CCL7/MCP-3		18 (9.874-30)		19.5 (10.93-30.9)	0.1931		619.5 (275.5-879.5)		731.6 (206.5-952.3)	0.1077
CCL11/Eotaxin		19.99 (8.792-37.74)		18.03 (9.54-43.23)	0.8475		68.86 (15.32-120.1)		75.98 (39.9-159.7)	0.441
CXCL9/MIG		333.5 (17.5-3001)		542.5 (74.97-7798)	0.3254		68.06 (4.366-413.3)		144 (18.91-307.8)	0.0568
CXCL10/IP-10		6608 (1730-12452)		7868 (833.7-23044)	0.1954		542 (12.02-1490)		574. (12.51-2896)	0.444
LIF		19 (2.161-45.5)		23 (8.214-53.5)	0.2329		24.31 (9.054-42.78)		35.87 (2.65-71.33)	0.0066
CXCL12/SDF-1α		55 (17.55-91.5)		53.48 (13.95-101)	0.6756	ND	ND	ND	ND	ND