Mediators of Inflammation

Research Article

Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto’s Thyroiditis Patients

Table 5

Effect of Hashimoto’s disease on growth factor levels: FGF: fibroblast growth factor; G-CSF: granulocyte colony-stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; M-CSF: macrophage colony-stimulating factor; PDGF-BB: platelet-derived growth factor–BB; VEGF: vascular endothelial growth factor.


	Saliva					Plasma
	Control group		Study group		value	Control group		Study group		value
		Median (min-max)		Median (min-max)	value		Median (min-max)		Median (min-max)	value

G-CSF		497 (363.1-649.2)		587.8 (344.1-894.8)	0.0066		590.2 (454.4-764.7)		726.8 (455.9-1162)	<0.0001
VEGF		1221 (53.24-3643)		2433 (634.8-6122)	0.0025		179.4 (91.19-331)		252.3 (24.03-608.9)	0.0842
TRIAL		441.3 (16.85-1154)		727.1 (24.71-4653)	0.0472		78.42 (26.96-143.5)		101.7 (12.02-191.1)	0.0878
FGF		5.412 (3.418-8.347)		5.54 (3.717-8.09)	0.3571		33.35 (19.34-46.92)		31.99 (17.48-54.19)	0.6443
GM-CSF		22.65 (11.77–37.98)		25.17 (5.405 –50.55)	0.5637		100.2 (70.8-140.6)		103.9 (48.13-146.8)	0.4762
M-CSF		206 (13.03-582.5)		238 (18.8-1301)	0.2182		69.24 (4.661-135.7)		98.87 (5.619-131.4)	0.0223
PDGF-BB		490 (103.6-740)		548.2 (111-1060)	0.5096		1092 (351.6-1689)		1095 (39.4-2135)	0.6305