Associations between TGF-β1 Levels and Markers of Hemolysis, Inflammation, and Tissue Remodeling in Pediatric Sickle Cell Patients

Figure 4

Associations between TGF-β1 levels and laboratory biomarkers as well as the glycoprotein TIMP-1 and matrixin MMP-9 in individuals with HbSC. Individuals with TGF-β1 levels above the median () exhibited increased (a) leukocytes, (b) eosinophils, (c) lymphocytes, (d) monocytes, and (e) platelets, as well as higher levels of (f) ferritin, (g) TIMP-1, and (h) MMP-9. All values were obtained by the Mann–Whitney test, except for leukocytes, monocytes, ferritin, and TIMP-1, for which the independent -test was used.

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