Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells

<div>Effects of nobiletin on TNF-induced CXCL10, CCL2, and IL-8 production in HPDLCs. HPDLCs were cultured with TNF (10 ng/ml) and nobiletin (12.5, 25, 50, or 100 <i>μ</i>M) for 24 hours. The amounts of CXCL10, CCL2, and IL-8 in the supernatants were determined using their respective ELISA kits. 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Mediators of Inflammation

fig2

Figure 2

Figure 2: Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells 