Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells

Figure 8

Effects of nobiletin on NFE2L2 and HMOX1 expression in TNF-stimulated HPDLCs. HPDLCs were stimulated by TNF (10 ng/ml) with or without nobiletin (25, 50, or 100 μM) for 24 hours, and then NFE2L2 and HMOX1 expression was determined by Western blot analysis. Each photograph is representative of the results of 3 separate experiments. The quantification was performed using image analysis software. compared to the TNF stimulation without nobiletin.