The Emerging Roles of CCN3 Protein in Immune-Related Diseases

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Diseases</td><td class="align_center">Mechanisms</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Osteoarthritis (OA)</td><td class="align_center">Decreases MMP, reduces extracellular matrix catabolism, and decreases the level of proinflammatory cytokines</td></tr><tr><td class="align_left">Glomerulonephritis (GN)</td><td class="align_center">Antifibrosis, inhibits mesangial cell growth, and inhibits the acceleration of ECM</td></tr><tr><td class="align_left">Metabolic diseases</td><td class="align_center">Inhibits the proliferation of pancreatic <i>β</i>-cells, regulates macrophage function, and regulates insulin signaling</td></tr><tr><td class="align_left">Multiple sclerosis (MS)</td><td class="align_center">Regulates Treg function and promotes myelin regeneration</td></tr><tr><td class="align_left">Systemic sclerosis (SSc)</td><td class="align_center">Antifibrosis, proangiogenesis, and controls extracellular matrix deposition</td></tr><tr><td class="align_left">Rheumatoid arthritis (RA)</td><td class="align_center">Decreases inflammatory cytokines</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Immune-related diseases influenced by CCN3.</div>

Mediators of Inflammation

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Table 1

Table 1: The Emerging Roles of CCN3 Protein in Immune-Related Diseases 