miR-708 Negatively Regulates TNFα/IL-1β Signaling by Suppressing NF-κB and Arachidonic Acid Pathways

Figure 7

Proposed model of miR-708-mediated negative regulation of TNFα/IL-1β signaling in diseased lung cells. Model representing the repressive effects of miR-708 on TNFα/IL-1β-mediated regulation of arachidonic acid and IL-6 signaling in A549 cells. Black arrows represent activated signaling pathways, while black dotted lines represent miR-708-inhibited signaling cascades. Green lettering and arrows indicate AA signaling, and red lines represent miR-708 target suppression.