Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway

<div>Cur prevented GF-induced aerobic glycolysis in HEK-293 cells. (a) pH in each group. (b) lac in each group. (c) PFK activity measured by colorimetric assay. (d) Western blot presenting PKM2 phosphorylation levels in each group. GF intensified aerobic glycolysis switch in HEK-293 cells, and Cur could weaken this intensification in a dose-dependent manner. Each error bar reflects the SEM of at least three independent sets.</div>

Mediators of Inflammation

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Figure 2

Figure 2: Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway 