The Role of CARD9 Deficiency in Neutrophils

Figure 2

Phosphorylated and dephosphorylated states of CARD9. In a resting state, Dok3 and PP1 combined with CARD9 in neutrophils, maintaining the inactive dephosphorylated state of CARD9. Upon Candida infection, the Dok3-PP1 complex dissociated from CARD9, and CARD9 was subsequently phosphorylated by PKCδ.