Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: “IFN-High,” “NE-High,” and “Mixed”

<div>Molecular subtypes in SLE samples in the discovery set. (a) The model was trained to predict three classes. NbClust, PAM (partitioning around medoids), and Vegan reveal that the optimal number of subtypes is three. Calling these three algorithms to classify patient samples, the results showed strong consistency. After further correction based on the consensus category, we got a more accurate result. (b) SLEDAI in the subtypes after correction. There are differences in the mean values of the three subtypes of SLEDAI, and the differences of overall and between subtypes are significant, reflecting the accurate allocation of samples after correction. (c) SLEDAI in the subtypes in the validation set.</div>

Mediators of Inflammation

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Figure 2

Figure 2: Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: “IFN-High,” “NE-High,” and “Mixed” 