Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: “IFN-High,” “NE-High,” and “Mixed”

<div>(a) Analysis of subtypes in functional modules. The function of disorders was divided into five modules: viral infection, bacterial infection, fungal infection, IFN disorder, and immune disorder. Each group of entries in the module represents BPs (biological processes), the height of the bars represents the degree of dysfunction, and the higher it is, the more serious the dysfunction. (b) Analysis of functional modules in subtypes. The middle circle represents the proportion of dysregulated functions in subtype, outer bars represent dysregulated functions, and the height of the bars represents the degree of dysregulation.</div>

Mediators of Inflammation

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Figure 3: Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: “IFN-High,” “NE-High,” and “Mixed” 