Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell

Figure 6

Diacerein inhibits cytokine-induced inflammation through attenuating AKT and NF-κB phosphorylation in ARPE-19 cells. TNF-α, IL-6, and IL-1β facilitated an increase in AKT and NF-κB phosphorylation levels in treated ARPE-19 cells compared to control cells. The phosphorylation level of AKT and NF-κB determined by western blotting. β-Actin was used as a reference control. Full-length blots are presented in Supplementary Figure 2. Quantification of protein expression levels by normalization to the internal control β-actin. Depicted western blots are one representative figure of three independent experiments. Results are the of three independent experiments.