[D-Ala<sup>2</sup>, D-Leu<sup>5</sup>] Enkephalin Inhibits TLR4/NF-<i>κ</i>B Signaling Pathway and Protects Rat Brains against Focal Ischemia-Reperfusion Injury

<div>Effects of DADLE on the protein bands of NF-<i>κ</i>B p65 expression in the ischemic penumbra at 24 hours after reperfusion (a). Quantitative analysis of NF-<i>κ</i>B p65 expression in (b). The expression of NF-<i>κ</i>B p65 protein was upregulated in the ACSF group and decreased after DADLE treatment. 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304 617C371 617 429 604 474 576C554 529 592 439 592 336C592 176 505 36 319 36C246 36 213 55 213 131V547Z"></path></g></svg> (group DADLE <span class="nowrap"><svg height="8.55521pt" id="M93" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 27.8368 8.55521" width="27.8368pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g 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Mediators of Inflammation

fig8

Figure 8

Figure 8: [D-Ala<sup>2</sup>, D-Leu<sup>5</sup>] Enkephalin Inhibits TLR4/NF-<i>κ</i>B Signaling Pathway and Protects Rat Brains against Focal Ischemia-Reperfusion Injury 

Mediators of Inflammation

[D-Ala2, D-Leu5] Enkephalin Inhibits TLR4/NF-κB Signaling Pathway and Protects Rat Brains against Focal Ischemia-Reperfusion Injury

Figure 8

[D-Ala², D-Leu⁵] Enkephalin Inhibits TLR4/NF-κB Signaling Pathway and Protects Rat Brains against Focal Ischemia-Reperfusion Injury