Research Article
Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Table 1
Characteristics of 77 patients with AAV.
| | Variables | Total () | Female () | Male () | value |
| | Demographic data | | | | | | Age (years) | 59.9 (14.5) | 59.7 (14.5) | 60.1 (14.7) | 0.891 | | Disease duration (months) | 18.2 (37.5) | 17.1 (30.3) | 19.6 (45.9) | 0.785 | | AAV subtypes (, (%)) | | | | | | MPA | 38 (49.4) | 22 (50.0) | 16 (48.5) | 0.896 | | GPA | 24 (31.2) | 12 (27.3) | 12 (36.4) | 0.397 | | EGPA | 15 (19.5) | 10 (22.7) | 5 (15.2) | 0.409 | | ANCA positivity (, (%)) | | | | | | MPO-ANCA (or P-ANCA) positive | 49 (63.6) | 29 (65.9) | 20 (60.6) | 0.634 | | PR3-ANCA (or C-ANCA) positive | 9 (11.7) | 6 (13.6) | 3 (9.1) | 0.725 | | Both ANCA positive | 3 (3.9) | 2 (4.5) | 1 (3.0) | 0.999 | | ANCA negative | 22 (28.6) | 11 (25.0) | 11 (33.3) | 0.426 | | AAV-specific indices | | | | | | BVAS | 9.8 (7.6) | 8.9 (7.4) | 11.0 (7.8) | 0.228 | | FFS | 1.3 (0.9) | 1.2 (0.9) | 1.5 (0.9) | 0.161 | | Clinical manifestations (, (%)) | | | | | | General manifestation | 28 (36.4) | 17 (38.6) | 11 (33.) | 0.634 | | Cutaneous manifestation | 7 (9.1) | 4 (9.1) | 3 (9.1) | 0.999 | | Mucous and ocular manifestation | 3 (3.9) | 3 (6.8) | 0 (0.0) | 0.256 | | Otorhinolaryngologic manifestation | 34 (44.2) | 23 (52.3) | 11 (33.3) | 0.100 | | Pulmonary manifestation | 45 (58.4) | 24 (54.5) | 21 (63.6) | 0.426 | | Cardiovascular manifestation | 4 (5.2) | 2 (4.5) | 2 (6.1) | 0.999 | | Gastrointestinal manifestation | 1 (1.3) | 1 (2.3) | 0 (0.0) | 0.999 | | Renal manifestation | 41 (53.2) | 18 (40.9) | 23 (69.7) | 0.013 | | Nervous systemic manifestation | 21 (27.3) | 14 (31.8) | 7 (21.2) | 0.304 | | Inflammation-related variables | | | | | | WBC count (/mm3) | 8,646.8 (4,285.0) | 8,380.5 (4,602.8) | 9,001.8 (3,861.7) | 0.532 | | Neutrophil count (/mm3) | 6,177.9 (3,424.8) | 5,929.5 (3,485.0) | 6,509.1 (3,367.2) | 0.466 | | Lymphocyte count (/mm3) | 1,503.6 (763.0) | 1,442.5 (717.0) | 1,585.2 (824.4) | 0.421 | | PLT count (×1,000/mm3) | 303.5 (144.4) | 293.9 (147.8) | 316.4 (140.9) | 0.502 | | Serum albumin (mg/dL) | 3.7 (0.7) | 3.8 (0.6) | 3.6 (0.8) | 0.180 | | ESR (mm/h) | 42.9 (36.3) | 44.0 (41.0) | 41.5 (29.4) | 0.763 | | CRP (mg/L) | 20.0 (40.5) | 21.6 (42.7) | 17.9 (37.9) | 0.697 | | Serum cytokines | | | | | | IL-27 (pg/mL) | 213.7 (214.7) | 193.2 (217.2) | 241.3 (211.3) | 0.333 | | IL-18 (pg/mL) | 327.0 (160.8) | 291.0 (143.5) | 375.1 (172.0) | 0.022 |
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Values are expressed as a or (%). ANCA: antineutrophil cytoplasmic antibody; AAV: ANCA-associated vasculitis; MPA: microscopic polyangiitis; GPA: granulomatosis with polyangiitis; EGPA: eosinophilic granulomatosis with polyangiitis; MPO: myeloperoxidase; P: perinuclear; PR3: proteinase 3; C: cytoplasmic; BVAS: Birmingham vasculitis activity score; FFS: five-factor score; WBC: white blood cell; PLT: platelet; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; IL: interleukin. |
