The Proresolving Lipid Mediator Maresin1 Alleviates Experimental Pancreatitis via Switching Macrophage Polarization

<div>MaR1 alleviated pancreatic tissue injury and fibrosis of pancreatic tissues in CP model. (a) Representative pathological changes in the pancreas after caerulein repetitive injection. HE-stained sections of the pancreas in magnification 100x and 200x and loss of pancreas area was quantified. (b) IHC examinations and total count for F4/80 of macrophages in the pancreas in magnification 200x. (c) Masson (the upper row) and Sirius red (the lower row) staining for collagen production in the pancreas of mice. <svg height="9.46863pt" id="M21" style="vertical-align:-1.11981pt" version="1.1" viewbox="-0.0498162 -8.34882 34.1002 9.46863" width="34.1002pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M531 285V335L57 550V494L473 310L57 127V71L531 285ZM531 -40V10H57V-40H531Z"></path></g><g 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group.</div>

Mediators of Inflammation

fig5

Figure 5

Figure 5: The Proresolving Lipid Mediator Maresin1 Alleviates Experimental Pancreatitis via Switching Macrophage Polarization 