Activation of Opioid Receptors Attenuates Ischemia/Reperfusion Injury in Skeletal Muscle Induced by Tourniquet Placement

Figure 6

Oxy treatment decreased TLR4 and NF-κB expression levels while increasing SIRT1 and PGC-1α levels in tourniquet-induced I/R in gastrocnemius muscle tissues. (a) Representative band images for TLR4, NF-κB, SIRT1, and PGC-1α in the I/R and Oxy-treated I/R groups. (b–e) Summary data showing expression of TLR4 (b), NF-κB (c), SIRT1 (d), and PGC-1α (e). I/R: ischemia-reperfusion; Oxy: oxycodone. Data are expressed as the ( in each group); vs. sham; ^# vs. I/R.

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