Key Factor Regulating Inflammatory Microenvironment, Metastasis, and Resistance in Breast Cancer: Interleukin-1 Signaling

Figure 3

IL-1 signaling-mediated intracellular signal transduction and activation in a breast cancer microenvironment. Abbreviations: IL—interleukin; IL-1R—IL-1 receptor; IL-1Ra—IL-1 receptor antagonist; HER2—human epidermal growth factor receptor 2; ERα—estrogen receptor alpha; PI3K—phosphoinositide 3-kinase; mTOR—mammalian/mechanistic target of rapamycin; NF-κB—nuclear factor kappa B; STAT3—signal transducer and activator of transcription 3; AhR—hydrocarbon receptor; RORγt—retinoid-related orphan nuclear receptor gamma t; CD4—cluster determinant 4; JNK—c-Jun N-terminal kinase; CXCR3—C-X-C chemokine receptor type 3; ZEB1—zinc-finger E-box binding protein 1; HIF-1α—hypoxia-inducible transcription factor-1 alpha; Wnt—wingless and int-1; CREB—cyclic AMP response-element binding protein; TG2—transglutaminase 2; TRAF6—TNF receptor-associated factor 6; NLRP3—NOD-like receptor family PYD domain-containing protein 3; NLRC4—NOD-like receptor family CARD-containing protein 4.