A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse

Table 1

Effects of NASP variant on splenic and lymph nodes’ lymphocyte subsets.

Lymphocyte subsets	Spleen		Lymph nodes
	Sle1.Yaa ()	Sle1.YaaΔsNASP ()	Sle1.Yaa ()	Sle1.YaaΔsNASP ()
CD3^+
CD19^+
CD3^+CD4^+
CD3^+CD8^+
CD19^+CD86^+
CD4^+CD69^+
Tfh (CD4^+CXCR5^+PD-1^+)
Breg (CD19^+CD5^+CD1d^high)
Th1 (CD4^+IFN-γ^+)
Th2 (CD4^+IL-4^+)
Th17 (CD4^+IL-17A^+)

Results are mean ± SEM; vs. Sle1.Yaa mice; vs. Sle1.Yaa mice.