Research Article
Analysis of Inflammatory Mediator Profiles in Sepsis Patients Reveals That Extracellular Histones Are Strongly Elevated in Nonsurvivors
Table 2
Biomarker profiles in sepsis patients at baseline (
).
| | Parameter | | Median | IQR (25th-75th quartile) |
| | Inflammatory mediators | | | | IL-1β | (pg/ml) | 6.82 | 4.37-14.55 | | IL-1ra | (pg/ml) | 670.66 | 266.44-1,231.08 | | IL-2 | (pg/ml) | 7.62 | 1.12-32.42 | | IL-4 | (pg/ml) | 6.36 | 4.82-10.11 | | IL-5 | (pg/ml) | 19.94 | 15.94-35.56 | | IL-6 | (pg/ml) | 277.02 | 103.65-1,091.49 | | IL-7 | (pg/ml) | 8.14 | 4.64-22.54 | | IL-8 | (pg/ml) | 104.56 | 53.26-198.48 | | IL-9 | (pg/ml) | 15.76 | 8.62-34.04 | | IL-10 | (pg/ml) | 28.48 | 10.59-65.04 | | IL-12 | (pg/ml) | 19.54 | 8.71-45.81 | | IL-13 | (pg/ml) | 6.68 | 0.84-11.68 | | IL-15 | (pg/ml) | 14.30 | 1.36-57.00 | | IL-17 | (pg/ml) | 49.22 | 19.65-86.74 | | IFN-γ | (pg/ml) | 173.40 | 112.79-295.45 | | TNF-α | (pg/ml) | 84.56 | 44.98-152.19 | | CRP | (mg/l) | 208.15 | 164.26-283.67 | | PCT | (ng/ml) | 3.00 | 0.78-4.36 | | LBP | (μg/ml) | 114.93 | 77.47-172.14 | | sCD14 | (ng/ml) | 3,159.00 | 2,728.00-3,721.00 | | sST2 | (ng/ml) | 372.36 | 173.64-589.74 | | Gas6 | (ng/ml) | 43.15 | 34.03-55.44 | | Chemokines | | | | | MCP-1 | (pg/ml) | 125.72 | 49.97-385.93 | | MIP-1α | (pg/ml) | 8.48 | 5.72-12.92 | | MIP-1β | (pg/ml) | 120.94 | 96.09-200.34 | | RANTES | (pg/ml) | 2,014.36 | 1,088.59-3,285.85 | | Eotaxin | (pg/ml) | 95.78 | 59.67-116.16 | | IP-10 | (pg/ml) | 1,375.94 | 822.83-2,734.51 | | Growth factors | | | | G-CSF | (pg/ml) | 161.60 | 70.82-637.97 | | GM-CSF | (pg/ml) | 54.32 | 13.46-109.47 | | FGF | (pg/ml) | 79.94 | 56.00-116.24 | | PDGF | (pg/ml) | 118.70 | 68.22-218.79 | | VEGF | (pg/ml) | 25.98 | 10.39-60.54 | | Endothelial activation markers | | | | ESM-1 | (ng/ml) | 6.00 | 3.86-12.95 | | Ang-1 | (ng/ml) | 0.59 | 0.43-1.22 | | Ang-2 | (ng/ml) | 13.85 | 7.85-33.21 | | Ang-2/Ang-1 | | 22.99 | 8.96-61.99 | | Damage-associated molecular patterns | | | ecDNAa | (ng/ml) | 545.02 | 276.11-1,194.48 | | Histonesa | (mg/ml) | 6.60 | 0.45-24.67 | | HMGB-1b | (ng/ml) | 3.70 | 2.6-6.91 | | Coagulation-related parameters | | | TF | (pg/ml) | 66.98 | 50.64-91.59 | | TF activity | (pM) | 38.13 | 24.57-55.79 | | Others | | | | | Cystatin C | (μg/ml) | 3.75 | 2.92-4.05 | | Albumin | (g/dl) | 3.38 | 2.83-3.81 |
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Data are represented as median and interquartile range (IQR, 25 th-75 th quartile). a; b. |
