Serum Inflammatory Factor Profiles in the Pathogenesis of High-Altitude Polycythemia and Mechanisms of Acclimation to High Altitudes

Figure 1

Differential expression patterns of inflammation factors by antibody array. (a, b) Array signals were scanned with an ImageQuant LAS4000 scanner, and signal values were statistically analyzed by Student’s -test. Differentially expressed inflammatory factors are shown by boxplots for comparisons with p values less than 0.05. The center line in the boxplots indicates the median for each data set. (c) Boxplot display of inflammation factors differentially expressed between PC and PUC. (d) Line chart of the six inflammatory factors differentially expressed among the four groups. Each line represents the level change of one of the six inflammation factors among the PC, PUC, eHAPC, and cHAPC groups. (e) The array profiles of the six inflammatory factors differentially expressed among the four groups. Each factor was measured in duplicate. Colored boxes indicate the locations of the six significantly different proteins on the arrays, and different colored boxes represent different cytokines. (f) The array data of these six inflammatory factors from the four groups are shown as a heat map, which was analyzed by Cluster 3.0 software. The levels of these proteins are represented by different colors. Low concentrations are in green, median concentrations are in black, and high concentrations are in red.

(a)

(b)

(c)

(d)

(e)

(f)