Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients
Table 1
Demographic and clinical features of CD patients.
All cases
Wild type (WT)
Polymorphism carriers (etero+omo)
Number of patients
191
125
66
Age of onset (yrs)
27 (21.5-38.5)
28 (23-43.5)
25 (19.25-34)
diagnosis-surgery (months)
12 (6-36)
12 (5-40)
12 (6-36)
Gender
Male
110 (58%)
68 (54%)
42 (64%)
Female
81 (42%)
57 (46%)
24 (36%)
Smoking habit
No
57 (33%)
31 (28%)
26 (44%)
Yes
54 (32%)
35 (31%)
19 (32%)
Former
60 (35%)
46 (41%)
14 (24%)
Pack years
15 (6-27)
18 (10-35)
9 (5-18)
Disease location
Ileo
112 (59%)
74 (59%)
38 (57%)
Colon
20 (10%)
15 (12%)
5 (8%)
Ileocolon
59 (31%)
36 (29%)
23 (35%)
Disease behavior
Inflammatory
20 (11%)
13 (10%)
7 (11%)
Stricturing
84 (44%)
57 (46%)
27 (41%)
Fistulising
18 (9%)
10 (8%)
8 (12%)
Stricturing and fistulising
69 (36%)
45 (36%)
24 (36%)
Extraintestinal disease
Skin
27 (14%)
19 (15%)
8 (12%)
Arthritis
60 (31%)
41 (33%)
19 (29%)
Perianal fistulae
65 (34%)
39 (31%)
26 (39%)
Medication responsiveness
Mesalazine
140 (92%)
94 (93%)
46 (88%)
Steroids
126 (81%)
80 (81%)
46 (82%)
Azathioprine
73 (72%)
44 (72%)
29 (73%)
Infliximab
33 (57%)
20 (54%)
13 (62%)
Adalimumab
46 (75%)
24 (75%)
22 (76%)
Type of surgery
Resection
157 (82%)
100 (80%)
55 (83%)
Resection+SXPL
34 (18%)
25 (20%)
11 (17%)
Recurrence
99 (52%)
64 (51%)
35 (53%)
Multiple operations (≥2)
99 (52%)
63 (50%)
36 (55%)
History of urgent surgery
47 (25%)
32 (26%)
15 (23%)
Minimum surgery-free interval (yrs)
3 (0.5-9)
3 (0.5-8)
3 (0.2-13.5)
Mean surgery-free interval (yrs)
5 (2-9)
5 (2-8)
5 (2-13.5)
Digestive cancer
5 (3%)
3 (2%)
2 (3%)
Extraintestinal cancer
9 (5%)
7 (6%)
2 (3%)
Immunological comorbidity
Autoimmunity
26 (14%)
17 (14%)
9 (14%)
Asthma
8 (4%)
4 (3%)
4 (6%)
Allergies
49 (26%)
28 (22%)
21 (32%)
Familial IBD
42 (26%)
29 (27%)
13 (24%)
Disease status
Quiescent
95 (66%)
56 (62%)
39 (74%)
Active
49 (34%)
35 (38%)
14 (26%)
Data are median (interquartile range 25–75) for continuous variables and number (percentage) for categorical variable. , WT vs. etero+omo, by or Mann–Whitney test.
