Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients
Table 3
Demographic and clinical features of polymorphism carriers.
Type of polymorphism
R702W
G881R
3020insC
Double variant
Number of patients
25
15
13
10
Age of onset (yrs)
24.5 (19-31.25)
29 (20-38)
22.5 (19.25-26.5)
28 (16-42.5)
diagnosis-surgery (months)
12 (4-12)
10 (6-43)
36 (12-84)
24 (12-55)
Gender
Male
15 (60%)
10 (67%)
6 (46%)
9 (90%)
Female
10 (40%)
5 (33%)
7 (54%)
1 (10%)
Smoking habit
No
6 (27%)
10 (72%)
7 (58%)
3 (33%)
Yes
9 (41%)
2 (14%)
3 (25%)
4 (45%)
Former
7 (32%)
2 (14%)
2 (17%)
2 (22%)
Disease status
Quiescent
17 (85%)
8 (61%)
9 (82%)
3 (43%)
Active
3 (15%)
5 (39%)
2 (18%)
4 (57%)
Disease location
Ileo
15 (60%)
8 (53%)
11 (84%)
2 (20%)
Colon
2 (8%)
0
1 (8%)
2 (20%)
Ileocolon
8 (32%)
7 (47%)
1 (8%)
6 (60%)
Disease behavior
Inflammatory
1 (4%)
1 (7%)
1 (8%)
1 (12%)
Stricturing
11 (46%)
7 (46%)
3 (25%)
4 (44%)
Fistulising
2 (8%)
1 (7%)
3 (25%)
2 (22%)
Stricturing and fistulising
10 (42%)
6 (40%)
5 (42%)
2 (22%)
Extraintestinal disease
Skin
4 (19%)
2 (14%)
1 (9%)
1 (14%)
Arthritis
7 (33%)
4 (28%)
5 (45%)
2 (28%)
Perianal fistulae
10 (40%)
4 (27%)
4 (33%)
6 (60%)
Medication responsiveness
Mesalazine
18 (95%)
9 (75%)
11 (100%)
6 (86%)
Steroids
16 (84%)
9 (64%)
11 (100%)
8 (89%)
Azathioprine
15 (100%)
5 (55%)
4 (44%)
4 (80%)
Infliximab
4 (50%)
1 (25%)
5 (100%)
3 (75%)
Adalimumab
9 (82%)
4 (67%)
7 (78%)
1 (50%)
Type of surgery
Resection
18 (86%)
12 (80%)
10 (83%)
9 (90%)
Resection+SXPL
3 (14%)
3 (20%)
2 (17%)
1 (10%)
Recurrence
9 (43%)
8 (53%)
8 (67%)
6 (67%)
Multiple operations (≥2)
9 (41%)
9 (60%)
8 (67%)
8 (80%)
History of urgent surgery
2 (9%)
5 (33%)
3 (25%)
5 (50%)
Minimum surgery-free interval (yrs)
Mean surgery-free interval (yrs)
Digestive and/or extraintestinal cancer
1 (4%)
1 (7%)
2 (14%)
0
Immunological comorbidity
Autoimmunity
3 (15%)
1 (8%)
3 (27%)
1 (14%)
Asthma
1 (5%)
0
2 (18%)
1 (14%)
Allergies
9 (45%)
5 (36%)
6 (54%)
1 (12%)
Familial IBD
6 (33%)
5 (36%)
1 (10%)
1 (11%)
Data are or median (interquartile range 25–75) for continuous variables and number (percentage) for categorical variable. , WT vs. etero+omo, by or Kruskal-Wallis test.
