Elevated Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 Level in Patients with Acute Coronary Syndrome (ACS): A Biomarker of Disease Severity and Outcome

Table 1

Epidemiological characteristics of the study patients.

	Nonspecific chest pain ()	Acute coronary ()	Health control ()	value
Plasma sTREM-1 pg/ml, median (i.q range)	402.2 (302.6-572.2)	429.4 (281.7-762.9)	218.9 (181.7-277.0)	<0.001
Age, mean (±SD)	54.1 (16.8)	58.4 (11.1)	42.6 (0.5)	<0.001
Males, (%)	38 (61.3)	49 (83.1)	39 (53.4)	0.002
IHD, (%)	9 (14.8)	30 (50.8)		<0.001
HTN, (%)	21 (33.9)	39 (66.1)		0.001
Diabetes, (%)	6 (9.7)	27 (45.8)		<0.001
Dyslipidemia, (%)	25 (40.3)	45 (76.3)		<0.001
Statin therapy, (%)	19 (30.6)	39 (66.1)	3 (4.1)	<0.001
Smoke status, (%)
Current	12 (20.3)	21 (35.6)		0.07
Past	14 (23.7)	13 (22.0)
Never	33 (55.9)	25 (42.4)
Family history of IHD, (%)	17 (28.8)	31 (55.4)		0.01
Obesity, (%)	10 (24.4)	29 (51.8)		0.01
BMI, mean (±SD)	27.1 (5.0)	28.6 (5.4)		0.21
Clinical presentation
Pulmonary edema, (%)	1 (1.6)	1 (1.7)		1.00
Cardiogenic shock, (%)	0	4 (6.8)		0.04
STEMI, (%)	0	22 (37.3)
NSTEMI, (%)	0	8 (13.6)
Unstable/stable angina	0	29 (49.2)
First troponin, median (i.q range)	0.0 (0.0-0.0)	15.0 (0.0-62.0)		<0.001
Second troponin, median (i.q range)	0.0 (0.0-21.7)	62.0 (0.0-1621.5)		<0.001
hrCRP, median (i.q range)	0.3 (0.1-0.6)	0.3 (0.2-0.7)		0.40
WBC	7.2 (2.1)	8.9 (3.0)		0.001
Creatinine	0.86 (0.22)	0.97 (0.32)	0.86 (0.20)	0.23
Heart score, median (i.q range)	2.0 (1.0-4.0)	5.0 (4.0-6.0)		<0.001
Grace score, median (i.q range)	0	100.0 (90.0-120.0)
ED treatment
Aspirin, (%)	3 (4.8)	41 (69.5)		<0.001
Plavix/Brilinta/Effient, (%)	0 (0.0)	18 (30.5)		<0.001
Heparin/LMWH, (%)	0 (0.0)	21 (35.6)		<0.001
Nitrates, (%)	1 (1.6)	8 (13.6)		0.01

i.q range: interquartile range.